Serratia marcescens-Contaminated Chlorhexidine
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چکیده
An investigation was conducted by researchers at the Royal Victoria Hospital and McGill University in Montreal, Quebec, Canada, and the University of Iowa College of Medicine to determine the source of an increase in the incidence of Serratia marcescens isolates, from a baseline in March 1992 of 2.7 per 1,000 admissions to 8.6 isolates per 1,000 admissions in November 1992. One hundred fifty-one patients located in many different areas of the hospital acquired infection (101) or colonization (50). The steep increase in isolates was related temporally to the introduction of a new chlorhexidine handwashing preparation, which did not contain isopropyl alcohol and which was distributed widely throughout the hospital. S marcescens was isolated from the chlorhexidine solution. Pulse-field gel electrophoresis performed on 25 patient isolates and 10 chlorhexidine isolates demonstrated a common DNA profile in 18 of 25 patient isolates and 7 of 10 chlorhexidine isolates. After recall of the solution, the incidence of S marcescens isolated from clinical specimens returned to the baseline rate. FROM: Vigeant P, Hollis R, Pfaller M, et al. An outbreak of Serratia marcescens associated with contaminated chlorhexidine. Presented at the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 17-20, 1995. Abstract J56.
منابع مشابه
Serratia marcescens outbreak due to contaminated 2% aqueous chlorhexidine.
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